Karakterisasi Sistem Dispersi Padat Meloksikam Dengan Matriks PEG 6000 Dan Poloxamer 188 Dibuat Dengan Menggunakan Metode Peleburan

Meloxicam is included in the class II Biopharmaceutical Classification System (BCS). This drug has low solubility and high permeability. The one of factors that affect dissolution rate drug. One effort to increase meloxicam by forming a solid dispersion system made using melting method. addition PEG 6000 poloxamer 188 carriers determine aims meloxicam. purpose this study characterize with matrices at ratio 99:1 98:2 method when compared physical mixture its pure compound Powder X-Ray Diffaction, DSC FTIR. results showed disappearance typical peak an angel 2θ 6.5° 11.2°. thermogram data shows decrease point namely 64.33°C 64.21°C. result characterization FTIR identified spectrum were range meloxicam, 6000, indicating there was no incteraction system. Keywords: Meloxicam, Poloxamer 188, Solid Dispersion, Melting Method, Characterization